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Substituted phenylimidazopyrazoles and their use
专利权人:
Bayer Intellectual Property GmbH;Bayer Pharma Aktiengesellschaft
发明人:
SÜßMEIER, Frank,LOBELL, Mario,GRÜNEWALD, Sylvia,HÄRTER, Michael,BUCHMANN, Bernd,TELSER, Joachim,JÖRIßEN, Hannah,HEROULT, Mélanie,KAHNERT, Antje,LUSTIG, Klemens,LINDNER, Niels
申请号:
ES13700765
公开号:
ES2639338T3
申请日:
2013.01.22
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
Compound of formula (I) ** Formula ^ ** in which ArN represents 5- or 6-membered aza-heteroaryl, which is selected from the group consisting of ** Formula ** where * links to the group imidazopyrazole and Y means O, S or NH, R1 represents hydrogen or fluorine, R2 represents hydrogen or (C1-C4) alkyl, R3 represents hydrogen, R4A and R4B independently of each other represent hydrogen, fluorine, chlorine, methyl, fluoromethyl, difluoromethyl, trifluoromethyl, hydroxymethyl, methoxymethyl, ethyl, hydroxy, methoxy or trifluoromethoxy, R5 represents hydrogen, fluorine, chlorine or methyl, R6 represents hydrogen, fluorine, methyl or hydroxy, Z1 represents C-R7A or N, Z2 represents C-R7B or N, Z3 represents C-R8 or N, Z4 represents C-R9 or N and Z5 represents C-R10 or N, where in total at most one of the ring members Z1, Z2, Z3, Z4 and Z5 represents N and where R7A and R7B independently of each other means hydrogen, fluorine, chlorine, methyl, hydroxy or methoxy, R8 means hi DROgenous, fluorine, chlorine or methyl, R9 means hydrogen, pentafluorosulfanyl, (trifluoromethyl) sulfanyl, trimethylsilyl, (C1-C6) alkyl, (C1-C6) alkoxy, cycloalkyl (C3-C6), oxetanyl or tetrahydropyranyl, where (C1 -C6) and (C1-C6) alkoxy can be substituted up to six times with fluorine and cycloalkyl (C3-C6), oxetanyl and tetrahydropyranyl can be substituted up to twice with identical or different moieties, selected from the fluorine series, methyl, trifluoromethyl and hydroxy, and R10 means hydrogen, fluorine, chlorine, bromine, cyano, (C1-C6) alkyl, hydroxy, (C1-C6) alkoxy, alkylsulfonyl (C1-C4), cycloalkyl (C3-C6), phenyl, heteroaryl 5 or 6 members or a group of the formula -L1-C (>; = O) -OR11, -L1-NR12AR12B, -L1-C (>; = O) -NR13AR13B, -L2-S (>; = O) 2 -NR13AR13B or -L3-R14, where (C1-C6) alkyl and (C1-C6) alkoxy can be substituted with a moiety selected from the hydroxy, methoxy, ethoxy, 2-hydroxyethoxy, 2-methoxyethoxy, 2-ethoxyethoxy series , amino, methylamino and tell me tilamino or ma
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