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СПОСОБ ПОЛУЧЕНИЯ МЕТАНСУЛЬФОНАТНЫХ СОЛЕЙ РАЛФИНАМИДА ИЛИ ИХ R-ЭНАНТИОМЕРОВ
专利权人:
发明人:
Клаудио,Эрвин
申请号:
EA201291116
公开号:
EA201291116A1
申请日:
2011.04.06
申请国别(地区):
EA
年份:
2013
代理人:
摘要:
the invention relates to a new method of obtaining and \/ or purification of salts of compound (s) - 2 - [4 - (2 - \u0444\u0442\u043e\u0440\u0431\u0435\u043d\u0437\u0438\u043b\u043e\u043a\u0441\u0438) \u0431\u0435\u043d\u0437\u0438\u043b\u0430\u043c\u0438\u043d\u043e] \u043f\u0440\u043e\u043f\u0430\u043d\u0430\u043c\u0438\u0434\u0430, have \u0440\u0430\u043b\u0444\u0438\u043d\u0430\u043c\u0438\u0434\u0430, or the major r enantiomer).and \u043c\u0435\u0442\u0430\u043d\u0441\u0443\u043b\u044c\u0444\u043e\u043a\u0438\u0441\u043b\u043e\u0442\u044b with high outputs and very high \u044d\u043d\u0430\u043d\u0442\u0438\u043e\u043c\u0435\u0440\u043d\u043e\u0439 and chemical degrees of purity in the form of crystalline anhydrous \u043f\u043e\u043b\u0438\u043c\u043e\u0440\u0444\u043d\u043e\u0439 \u043c\u043e\u0434\u0438\u0444\u0438\u043a\u0430\u0446 ai, identified as uniform as well.where the salt is substantially free of impurities, with \u0433\u0435\u043d\u043e\u0442\u043e\u043a\u0441\u0438\u0447\u0435\u0441\u043a\u0438\u0439 effect, such as (c1 - c5) \u0430\u043b\u043a\u0430\u043d\u0438\u043b\u043c\u0435\u0442\u0430\u043d\u0441\u0443\u043b\u044c\u0444\u043e\u043d\u0430\u0442\u044b and residual races \u0442\u0432\u043e\u0440\u0438\u0442\u0435\u043b\u0435\u0439,known as their potential substances - predecessors such as (c1 - c5) \u0430\u043b\u043a\u0430\u043d\u043e\u043b\u044b or esters \u0430\u043b\u043a\u0430\u043d\u043e\u043b\u043e\u0432 and lower \u0430\u043b\u043a\u0430\u043d\u043e\u0432\u044b\u0445 acids.method for (i) receiving and \/ or crystallization of salt from water, acetone, \u0430\u043b\u0438\u0444\u0430\u0442\u0438\u0447\u0435\u0441\u043a\u043e\u0433\u043e \u043a\u0435\u0442\u043e\u043d\u0430 with 4 to 5 carbon atoms, or their mixture with water.or (ii) \u0441\u0443\u0441\u043f\u0435\u043d\u0434\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u0435 solid salt (a) water, (b) with a mixture of water with acetone or wiped \u043a\u0435\u0442\u043e\u043d\u043e\u043c with
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