(57)< Abstract > This invention being method in order to reverse the cancer sex expression type of the cancer cell, offers the method of reversing the cancer sex expression type of the aforementioned cancer cell the nuclear acid which includes the melanoma differentiation-related gene (mda-7), by introducing into the aforementioned cancer cell under the condition revelation of the aforementioned gene being possible. As for this invention, in addition, being method in order to reverse the cancer sex expression type of the cancer cell, it offers the method of reversing the cancer sex expression type of the aforementioned cancer cell by introducing the gene product of the above-mentioned gene into the aforementioned cancer sex cell. This invention furthermore, offers the pharmacy composition which contains with the nuclear acid of the fixed quantity which includes the melanoma differentiation-related gene (mda-7) which is effective in order to reverse the cancer sex expression type of the cancer cell or the gene product of the melanoma differentiation-related gene (mda-7) and pharmacy the approved possible carrier.本発明は、がん細胞のがん性表現型を反転させるための方法であって、メラノーマ分化関連遺伝子(mda-7)を含む核酸を、前記遺伝子の発現が可能な条件下で前記がん細胞に導入することにより、前記がん細胞のがん性表現型を反転させる方法を提供する。本発明は、また、がん細胞のがん性表現型を反転させるための方法であって、上記遺伝子の遺伝子産物を前記がん性細胞に導入することにより、前記がん細胞のがん性表現型を反転させる方法を提供する。本発明は、さらに、がん細胞のがん性表現型を反転させるために有効なメラノーマ分化関連遺伝子(mda-7)を含む一定量の核酸またはメラノーマ分化関連遺伝子(mda-7)の遺伝子産物と、薬学的に許容可能なキャリアとを含有する薬学的組成物を提供する。
