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Antibody drug conjugate (adc) purification
专利权人:
发明人:
LEANNA MARVIN ROBERT,BECKER CALVIN LAWRENCE
申请号:
IN8581/DELNP/2015
公开号:
IN2015DN08581A
申请日:
2015.09.18
申请国别(地区):
IN
年份:
2016
代理人:
摘要:
The invention provides methods for obtaining compositions having antibody drug conjugates (ADCs) with specified drug to antibody ratios (DARs). Included in the invention is a method for purifying an ADC mixture having ADCs with a drug loaded species of 6 or more by contacting the mixture with a hydrophobic resin such that a composition comprising less than 15% of the 6 or more drug loaded species is obtained. The invention also provides a composition wherein 70% or more of the ADCs present have a drug loaded species of 4 or less wherein the ADC comprises an anti EGFR antibody and an auristatin.
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