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4,4-DISUBSTITUTED-1,4-DIHYDROPYRIMIDINES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B
专利权人:
Janssen R&D Ireland
发明人:
Koen Vandyck,Geerwin Yvonne Paul Haché,Geert Rombouts,Wim Gaston Verschueren,Pierre Jean-Marie Raboisson
申请号:
US14370118
公开号:
US20150005295A1
申请日:
2013.01.04
申请国别(地区):
US
年份:
2015
代理人:
摘要:
Inhibitors of HBV replication of formula (I) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein R1-R5, B and Z have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.
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