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METHODS FOR THE PURIFICATION OF POLYPEPTIDE CONJUGATES
专利权人:
NOVO NORDISK A/S
发明人:
DEFREES, SHAWN,KINEALY, KYLE
申请号:
EP07868365
公开号:
EP2054521A4
申请日:
2007.10.03
申请国别(地区):
EP
年份:
2012
代理人:
摘要:
The present invention provides processes for the manufacturing of polypeptide conjugates. In particular, the invention provides methods for the purification of polypeptide conjugates, which include at least one polymeric modifying groups, such as a poly(alkylene oxide) moiety. Exemplary poly(alkylene oxide) moieties include poly(ethylene glycol) (PEG) and poly(propylene glycol). In an exemplary process, hydrophobic interaction chromatography (HIC) is used to resolve different glycoforms of glycoPEGylated polypeptides.
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中国工程科技知识中心
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