Dong Yizhou,Love Kevin Thomas,Langer Robert S.,Anderson Daniel Griffith,Chen Delai,Chen Yi,Vegas Arturo Jose,Alabi Akinleye,Zhang Yunlong
申请号：
NZ71994112
公开号：
NZ719941A
申请日:
2012.10.26
申请国别(地区):
NZ
年份:
2017
代理人:
摘要：
Described herein are compounds and compositions that are characterized by the Markush formulae (I), (II), (III), (IV), (V), and (VI) underneath, where at least one terminal amino group is further functionalized by bearing a group of type (i), (ii), or (iii). Such compounds are obtained by reacting a terminal or internal amino group with epoxides, acrylates, or aldehydes bearing lipophilic groups. The resulting amino acid, peptide, polypeptide-lipids (named “APPLs” in the application) are deemed useful as drug delivery systems including nucleotide delivery to cells.
