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Oligonucleotides for genomic DNA editing
专利权人:
ProQR Therapeutics II B.V.
发明人:
Holkers, Maarten,Swildens, Jim
申请号:
AU2015334835
公开号:
AU2015334835A1
申请日:
2015.10.23
申请国别(地区):
AU
年份:
2017
代理人:
摘要:
A method for making a change in an endogenous chromosomal DNA sequence of a mammalian cell, comprising steps of: (i) introducing into said cell an oligonucleotide having a sequence that is complementary to the chromosomal DNA sequence and that includes the change; (ii) allowing sufficient time for the cell to incorporate the change into the endogenous chromosomal DNA sequence through endogenous nucleic acid modifying pathways; and (iii) identifying the presence of the change in the chromosomal DNA sequence. The invention is particularly useful for correcting mutations in the CFTR gene.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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