A pharmaceutical composition of 3-(1-{3-[5-(1-Methyl-piperidin-4-ylmethoxy)-pyrimidin-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile or a pharmaceutically acceptable salt and/or solvate thereof in combination with Gefitinib.本發明係關於一種藥物組合物,其係3-(1-{3-[5-(1-甲基-哌啶-4-基甲氧基)-嘧啶-2-基]-苄基}-6-側氧基-1,6-二氫嗒-3-基)-苯甲腈或其藥學上可接受之鹽及/或溶劑化物與吉非替尼(Gefitinib)組合。