The pharmaceutical compositions for prevention or treatment of inflammatory spine disease containing Scolopendra subspinipes and Peony as an active ingredient
The present invention relates to a pharmaceutical composition for the prevention and treatment of inflammatory spinal diseases, comprising a peony and a pit extract as an active ingredient, wherein the peony and pit mixed extracts exhibit a concentration-dependent inhibitory effect on nitric oxide production and cytokine production, And it was confirmed that ear edema was alleviated in a concentration dependent manner by the mixed extract in ear edema-induced mouse model. Further, it was confirmed that ear edema was alleviated by the mixed extract in ear edema-induced mouse model, It was confirmed that the mixed extract of the present invention had the best inhibitory effect on inflammation. As a result, it was confirmed that the pain was alleviated and the disk was improved by administering it as a herb to a patient with herniated disc herniation. The composition is useful for the prevention and treatment of inflammatory spinal diseases It can be used and may be useful to use acupuncture for the prevention and treatment of inflammatory spinal disease.본 발명은 작약 및 오공 추출물을 유효성분으로 함유하는 염증성 척추질환 예방 및 치료용 약학적 조성물에 관한 것으로, 작약 및 오공 혼합 추출물이 농도 의존적으로 산화질소 생성 및 사이토카인 생성 억제 효과를 나타내어 염증 반응 억제 효과가 우수함을 확인하였으며, 귀 부종 유발 마우스 모델에서 혼합 추출물에 의해 농도 의존적으로 귀 부종이 완화됨을 확인하였고, 또한 상기 작약 및 오공 추출물에 추가적으로 구척, 강활, 두충, 우슬, 오가피, 방풍 및 독활을 혼합한 혼합 추출물에서 염증 반응 억제 효과가 가장 우수함을 확인하였으며, 이를 추간판탈출증 환자에게 약침으로 투여한 결과, 통증이 완화되고 디스크가 호전됨을 확인함으로써, 본 발명의 작약 및 오공 추출물을 함유하는 약학적 조성물은 염증성 척추질환 예방 및 치료에 유용하게 이용될 수 있으며, 염증성 척추질환 예방 및 치료용 약침에 유용하게 이용될 수 있다.
