PSMA BINDING LIGAND-LINKER CONJUGATES AND METHODS FOR USING

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专利权人:

PURDUE RESEARCH FOUNDATION

发明人:

LOW, PHILIP, STEWART,KULARATNE, SUMITH, A

申请号：

NZ58393108

公开号：

NZ583931A

申请日:

2008.08.15

申请国别(地区):

NZ

年份:

2012

代理人:

摘要：

Disclosed is a conjugate having the formula B-L-D, wherein B is a prostate specific membrane antigen (PSMA) binding or targeting ligand, L is a linker, and D is a drug, wherein the linker is covalently bound to the drug and the linker is covalently bound to the ligand, and where the linker comprises a chain of at least seven atoms providing that the ligand is not an antibody or antigen-binding fragment of an antibody.

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