Derek Marshall;Donna Hiroko Tokuoka Biermann;Miho Oyasu;Alison Kay Holzer;Carlos Aurelio Garcia;Peter Van Vlasselaer;Victoria Smith;Vivian E. Barry;Hector Rodriguez;Scott Alan McCauley;Scott Ogg
发明人:
Victoria Smith,Scott Ogg,Peter Van Vlasselaer,Vivian E. Barry,Derek Marshall,Alison Kay Holzer,Hector Rodriguez,Miho Oyasu,Scott Alan McCauley,Carlos Aurelio Garcia,Donna Hiroko Tokuoka Biermann
申请号：
US12185054
公开号：
US08679485B2
申请日:
2008.08.01
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present disclosure provides methodology and compositions for preventing and treating various diseases associated with abnormal cell proliferation, angiogenesis and fibrosis, by using an inhibitor of processed forms of lysyl oxidase or lysyl oxidase-like proteins, an inhibitor of LOX or LOXL, or a synergistic combination thereof combined with other therapeutic agents. Methods and compositions for diagnosing or monitoring various diseases associated with abnormal cell proliferation, angiogenesis and fibrosis, are also provided. Also provided herein are methods and related compositions, medical devices, systems and kits for preventing or treating various diseases and conditions associated with fibrosis with compositions comprising inhibitors of LOX or LOXL.
