對ＣＤ１２３具專一性之抗體和抗體－藥物共軛體及彼等之用途农业专利-农业学术服务平台

发明人:: CHARATI, MANOJ BABURAO,查拉提　马诺,查拉提　馬諾,HAN, YOON-CHI,韩　尹智,韓　尹智,KATRAGADDA, MADAN,卡拉格达　马丹,卡拉格達　馬丹,PICHE-NICHOLAS, NICOLE MELISSA,皮尼古拉　妮可,TUMEY, LAWRENCE N.,图梅　劳伦斯,圖梅　勞倫斯

摘要：: The present invention provides antibodies that specifically bind to CD123. The invention further relates to immunoconjugates (e.g., antibody-drug conjugates, or ADCs) comprising such antibodies, antibody encoding nucleic acids, and methods of obtaining such antibodies. The invention further relates to therapeutic methods for use of these antibodies and ADCs for the treatment of a condition associated with cells expressing CD123 (e.g., cancer or autoimmune disease).本發明提供與CD123專一性結合之抗體。本發明進一步關於包含該等抗體之免疫共軛體(例如抗體-藥物共軛體或ADC)、編碼抗體之核酸及獲得該等抗體之方法。本發明進一步關於使用該等抗體及ADC以治療與表現CD123之細胞有關之病症(例如癌症或自體免疫性疾病)之治療方法。