Fudan University;The United States Of America, As Represented By The Secretary, Department Of Health And Human Services
发明人:
申请号：
EP19189394.0
公开号：
EP3590961A1
申请日:
2015.12.16
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
The invention provides a construct comprising two or more fusion proteins of Formulas (I)-(IV): A-(optional linker)-C-(optional linker)-B (Formula I), B-(optional linker)-D-(optional linker)-E-(optional linker)-B (Formula II), A-(optional linker)-C (Formula III), and B-(optional linker)-D-(optional linker)-E (Formula IV), wherein A denotes an antibody or antibody fragment, B denotes a single domain CD4, C denotes an immunoglobulin light chain constant region, D denotes an immunoglobulin heavy chain constant region, and E denotes an Fc region or a portion thereof that is optionally defucosylated.
