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SOLUTIONS STÉRILES D'ACIDE HYALURONIQUE
专利权人:
BAUSCH & LOMB INCORPORATED
发明人:
申请号:
EP11702563.5
公开号:
EP2400993B1
申请日:
2011.01.27
申请国别(地区):
EP
年份:
2014
代理人:
摘要:
A process for sterilizing a solution comprising hyaluronic acid. The process comprises providing an aqueous solution of hyaluronic acid with a weight average molecular weight from 0.6 MDa to 3.6 MDa, and the concentration of the hyaluronic acid is from 0.04 % to 0.8 % by weight. The aqueous solution also has an ionic strength equivalent to an aqueous concentration of sodium chloride from 3 % to 30 % by weight. Once the aqueous, high salt, hyaluronic acid solution is prepared the solution is maintained at a temperature from 40°C to 80°C for at least 1 hour and not longer than six days. Following the heat treatment step, the aqueous solution is filtered through a sterilization filter medium to provide a sterilized high salt, hyaluronic acid solution.
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