Venu Raman,Guus Martinus Bol,Paul Joannes Van Diest
申请号：
US13840549
公开号：
US09322831B2
申请日:
2013.03.15
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The invention encompasses methods for treating or preventing diseases and disorders associated abnormal cell growth, for example, treating or preventing cancer or tumor growth, by administering to a subject in need thereof a composition comprising a therapeutically or prophylactically effective amount of a compound that downregulates DDX3, for example a fused diimidazodiazepine ring compound or a pharmaceutically acceptable salt thereof. The invention also encompasses the use of DDX3 as a biomarker for diagnostic and treatment purposes, for example, to identify a hyperproliferative disorder susceptible to treatment by down regulation of DDX3.
