A bioreactor (100) for a vascularized structure (200) is provided comprising a vasculated portion (202) and a vascular pedicle (204), the bioreactor (100) comprising a first void space (112) configured to receive the vascular pedicle (204) optionally contained in a first vessel (110) having a first opening (114), a second void space (142) in fluid contact with at least part of the vasculated portion (202), and a support element (170) for supporting the vascularized structure (200) and fluidly separating the first void space (112) from the second void space (142), comprising an aperture region (176) comprising one or more apertures configured to receive at least part of the vascular pedicle (204).
