The United States of America; as represented by the Secretary; Department of Health and Human Services
发明人:
Morgan, Richard A.,Rosenberg, Steven A.
申请号：
AU2012240562
公开号：
AU2012240562A1
申请日:
2012.03.21
申请国别(地区):
AU
年份:
2013
代理人:
摘要：
The disclosure provides chimeric antigen receptors (CARs) comprising an antigen binding domain of human antibody 139, an extracellular hinge domain, a transmembrane domain, and an intracellular domain T cell receptor signaling domain. Nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions relating to the CARs are disclosed. Methods of detecting the presence of cancer in a host and methods of treating or preventing cancer in a host are also disclosed.
