ДАДЛИ Роберт И. (US),КОНСТАНТИНИДЕС Панайотис П. (US)
申请号：
RU2011119796/15
公开号：
RU2011119796A
申请日:
2011.05.17
申请国别(地区):
RU
年份:
2012
代理人:
摘要：
1. A pharmaceutical composition comprising: a) testosterone ester, including testosterone enanthate (TE), testosterone undecanoate (TU), or both； b) and two or more lipid components, at least the first of which includes a hydrophilic surfactant, and at least the second of which includes lipophilic surfactant, these lipid components together provide the solubilization of testosterone ester. 2. The pharmaceutical composition according to claim 1, which comprises at least three lipid components, at least the first of which includes a hydrophilic surfactant, at least the second and third of which include a lipophilic surfactant, each of which solubilizes the testosterone ester. The pharmaceutical composition according to claim 2, which further comprises a second fat-soluble therapeutic agent. The pharmaceutical composition according to claim 3, wherein the second fat-soluble therapeutic agent comprises synthetic progestin, type 5 and / or type 5α-reductase inhibitor, finasteride, dutasteride, or a combination thereof. The pharmaceutical composition according to claim 1, in which at least the first lipid component has an HLB of from 10 to 45.6. The pharmaceutical composition of claim 5, wherein at least the first lipid component is Cremophor EL, Cremophor RH 40, Etocas 35, Etocas 40, and a combination thereof. The pharmaceutical composition of claim 1, wherein at least the first lipid component is glycerol and its PEG esters. The pharmaceutical composition according to claim 7, in which at least the first lipid component is Cremophor RH 40.9. The pharmaceutical composition according to claim 1, in which at least the second lipid component has an HLB of less than 10.10. Farm1. Фармацевтическая композиция, включающая:а) эфир тестостерона, включая тестостерона энантат (ТЭ), тестостерона ундеканоат (ТУ), или оба из них；б) и два или более липидных компонента, по крайней мере первый из которых включает гидрофильный сурфактант, и по крайней мере второй из которых включает липоф
