Variants derived from ActRIIB and uses therefor

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专利权人:

Acceleron Pharma Inc.

发明人:

Knopf, John,Kumar, Ravindra,Seehra, Jasbir

申请号：

AU2016208313

公开号：

AU2016208313A1

申请日:

2016.07.27

申请国别(地区):

AU

年份:

2016

代理人:

摘要：

#$%^&*AU2016208313A120160811.pdf#####ABSTRACT In certain aspects, the present invention provides compositions and methods for modulating (promoting or inhibiting) growth of a tissue, such as bone, cartilage, muscle, fat, and/or neuronal tissue. The present invention also provides methods of screening compounds that modulate activity of an ActRIIB protein and/or an ActRIIB ligand. The compositions and methods provided herein are useful in treating diseases associated with abnormal activity of an ActRIIB protein and/or an ActRIIB ligand.

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