리 타이-웨이,요시노 타카시,타케카와 유키,신타니 타쿠야,수지모토, 히로미,바콘, 케빈. 비,얼반스, 클라우스
申请号：
KR1020067017478
公开号：
KR1012074280000B1
申请日:
2005.01.19
申请国别(地区):
KR
年份:
2012
代理人:
摘要：
The present invention is useful as an active ingredient of pharmaceutical preparations imidazo [1,2-c] pyrimidinyl acetic acid derivatives (imidazo [1, 2-c] pyrimidinylacetic acid derivative) and to a salt thereof. Of the present invention imidazo [1,2-c] pyrimidinyl acetic acid derivatives (G- protein expressed on Th2 cell-coupled-- receptor (G-protein-coupled chemoattractant receptor)) CRTH2 activity opposite to the (antagonistic activity ) has. And can be used for the prevention and treatment of diseases associated with CRTH2 activity. In particular, asthma (asthma), allergic rhinitis (allergic rhinitis), atopic dermatitis (atopic dermatitis), allergic conjunctivitis (allergic conjunctivitis) and allergic diseases such as (allergic disease), cheogeu Strauss syndrome (Churg-Strauss syndrome), and venous sinusitis (sinusitis), such as eosinophils (eosinophil) related illness in humans and other mammals basophilic leukemia (basophilic leukemia), urticaria (chronic urticaria) and call-related diseases such as basophils basic leukocytosis (basophilic leukocytosis) (basophil-related disease), psoriasis (psoriasis), eczema (eczema), inflammatory bowel disease (inflammatory bowel disease), ulcerative colitis (ulcerative colitis), Crohns disease (Crohns disease), COPD (chronic obstructive pulmonary disorder) and arthritis characterized by (arthritis), such as T lymphocytes and leukocyte-rich infiltrates (profuse leukocyte infiltrates) may be used in the treatment of inflammatory disease.본 발명은 약학 제제의 유효 성분으로서 유용한 이미다조[1,2-c]피리미디닐아세트산 유도체(imidazo [1, 2-c] pyrimidinylacetic acid derivative) 및 그의 염에 관한 것이다. 본 발명의 이미다조[1,2-c]피리미디닐아세트산 유도체는 CRTH2(Th2 세포에서 발현되는 G-프로테인-커플드-리셉터(G-protein-coupled chemoattractant receptor))과 상반되는 활성(antagonistic activity)을 갖는다. 그리고, CRTH2 활성과 관련된 질병의 예방 및 치료를 위해 사용될 수 있다. 특별히, 천식(asthma), 알레르기성 비염(allergic rhinitis), 아토피 피부염(atopic dermatitis), 알레르기성 결막염(allergic conjunctivitis)과 같은 알레르기성 질병(allergic disease), 처그스트라우스증후군(Churg- Strauss syndrome) 및 정
