Described are embodiments of methods and devices for removing adipose tissue from a surgical site or location in a patients body. The embodiments include a device that is used for infiltration, ultrasound, and aspiration of the surgical site. The device includes a cannula which serves to provide infiltration, conduct ultrasonic energy from an ultrasound generating device, and also provide a conduit for aspiration to a fluid system used for infiltration and collection of fluids. Embodiments provide for a fixed amount of infiltration fluid to be injected into the surgical site in specific ratio with the amount of lipoaspirate to be removed. The fixed amount of ultrasonic energy, both in amplitude and time, is delivered to the surgical site commensurate with the amount of infiltration and aspiration. The device also includes, in embodiments, a guide that limits the depth to which the cannula can be inserted into a patient.