The present invention relates to the polymorph crystals variant of 1- [(4- methyl-quinazoline -2- bases) methyl] -3- methyl -7- (2- butine -1- bases) -8- (3- (R)-amino-piperadine -1- bases)-xanthine, preparation method and its purposes in medicine preparation.本發明涉及1-[(4-甲基-喹唑啉-2-基)甲基]-3-甲基-7-(2-丁炔-1-基)-8-(3-(R)-氨基-哌啶-1-基)-黃嘌呤的多晶型晶體變體、其製備方法及其在製備藥物中的用途。