KUHN, Michael Harald,MUZEL, Christine Charlotte Jutta,HENDRIKS, Bernardus Hendrikus Wilhelmus,LUCASSEN, Gerhardus Wilhelmus
申请号：
IBIB2013/052385
公开号：
WO2013/144830A2
申请日:
2013.03.26
申请国别(地区):
WO
年份:
2013
代理人:
摘要：
A Photodynamic Therapy (PDT) system with an elongated interventional device (IDV) with a bundle of optical fibers (F1, F2, F3) forming respective light exit ports which can be individually accessed. The bundle has an optical shape sensing fiber (OSS), e.g. including Fiber Bragg Gratings, arranged for sensing position and orientation (P_O) of the light exit ports. A processor executes a control algorithm which generate a light dose signal (LDS) to allow generation of light outputs (LD1, LD2, LD3) to the plurality of optical fibers (F1, F2, F3) accordingly. The control algorithm generates the light dose signal (LDS) in response to the determined position and orientation of the light exit ports (P_O), and three- dimensional body anatomy image information obtained by a first image modality (I1), e.g. X- ray, MRI, CT, ultrasound, or PET-CT. This combination allows precise application of a light dose distribution for PDT treatment of a tumor with a minimal destruction of connective tissue. In embodiments, the control algorithm takes image information regarding distribution of a photosensitizer in the body tissue (I2) as input. The control algorithm may further take into account image information regarding a concentration of oxygen in the body tissue (I3). Both of such inputs allow a more precise PDT light application.Linvention concerne un système de thérapie photodynamique (TPD) avec un dispositif dintervention (DI) allongé comportant un faisceau de fibres optiques (F1, F2, F3) formant des ports de sortie de lumière respectifs auxquels on peut accéder individuellement. Le faisceau a une fibre détectant les formes optiques (DFO), par ex. incluant des réseaux de Bragg sur fibre, agencés pour détecter la position et lorientation (P_O) des ports de sortie de lumière. Un processeur exécute un algorithme de commande qui génère un signal de dose de lumière (SDL) pour permettre la génération de sorties de lumière (LD1, LD2, LD3) vers la pluralité de fibres optiques (F1, F2, F3)
