AN, DEQIANG,HAN, NIANHE,ZENG, DI,YANG, HANG,ZHU, PENG,LI, MINGZHEN,JIAN, LI,YANG, CHUN
申请号：
EP14743793
公开号：
EP2949343A4
申请日:
2014.01.17
申请国别(地区):
EP
年份:
2016
代理人:
摘要：
Disclosed are a type of tridentate linkers and use thereof. The tridentate linkers can be used to prepare an antibody drug conjugates as represented by formula I, wherein, L is an antibody, antibody fragment or protein； T is a tridentate linker part； A is a cleavable linker group or a noncleavable linker part； D is a drug part； n is an integer of 0-8. The structure of the tridentate linker part is as represented by formula II, wherein, W is substituted aryl, heteroaryl, linear alkyl, cycloalkyl, heterocycloalkyl, or any combination thereof. €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ L -(T-A-D) n €ƒ€ƒ€ƒ€ƒ€ƒ I
