RHODES, Christopher A.,MALAVIA, Nikita,JENNINGS, Robert,LAXMA, Reddy,NORMAN, Betty
申请号：
AU2020202040
公开号：
AU2020202040A1
申请日:
2020.03.20
申请国别(地区):
AU
年份:
2020
代理人:
摘要：
#$%^&*AU2020202040A120200409.pdf#####ABSTRACT Microparticles are prepared by a method that includes: (a) forming a layer comprising a first polymer on a solid surface by depositing a first composition one or more times on the solid surface, wherein the first composition comprises the first polymer and a first solvent, and evaporating the first solvent in the first composition； (b) forming one or more layers comprising a second polymer and a therapeutic agent by depositing a second composition on all or part of the layer formed in step (a), wherein the second composition comprises the second polymer, the therapeutic agent, and a second solvent； and evaporating the second solvent in the second composition； and (e) forming an additional layer comprising a third polymer by depositing a third composition one or more times on a previously formed layer, wherein the third composition comprises the third polymer and a third solvent； and evaporating the third solvent in the third composition. SOa Altk 100 60 ... ... ... ... 10 Weeks Sample Sample Drug Inner Layer Polymer Outer Layer No. Description Load Polymer (% w/w) Sample 1 Brinzolamide 11S9 115 kDa PLGA None suspension in (Evonik Industries/ dicholoromethane Lakeshore Biomnaterials 7525 DLG 7E) Sample 2 Brinzolamide 10.2 115 kDa PLGA Two coatings of suspension in (Evonik Industries/ 5% 178 kDa dicholoromethane Lakeshore Bion materials PLGA (Akina 7525 DLG 7E) 8520)1/3 100 90 r~rt a#Aa 20 ~70 0 0 0£ Sampl Sample Du ne LyrPlmr ue ae No Decito Load Polymer 0***~*........... No. ~ ~ (% w/w) ______ Sample 1 Brinzolamide 11.9 115 kDa PLGA None suspension in (Evonik Industries! dicholoromethane Lakeshore Biomaterials 7525 DLG 7E) ________ Sample 2 Brinzolamide 10.2 115 kDa PLGA Twvocoatings of suspension in (Evonik Industries! 5% 178 kDa dicholoromethane Lakeshore Biomaterials PLGA (Akina 7525 DLG 7E) 8520) Fig. 1
