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Polymorphs of efavirenz
专利权人:
Bandi Parthasaradhi Reddy
发明人:
Bandi Parthasaradhi Reddy,Kura Rathnakar Reddy,Rapolu Raji Reddy,Dasari Muralidhara Reddy,Kesireddy Subash Chander Reddy
申请号:
US13174893
公开号:
US08242267B2
申请日:
2011.07.01
申请国别(地区):
US
年份:
2012
代理人:
摘要:
The present invention relates to novel amorphous and crystalline forms of efavirenz, processes for their preparation and pharmaceutical compositions containing them. In accordance with the present invention efavirenz crude is dissolved in acetone at 25° C.-30° C., the solution is slowly added to water for 30 minutes at 0° C.-5° C., stirred for 1 hour at the same temperature, the separated solid is filtered, washed with water and dried at 55° C.-60° C. for 5 hours to give amorphous efavirenz.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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