[problem] in order to provide a kind of drug or composition, wherein the herbal medicine or extract of effective component have the expression BDNF genes of induced activity. Radix Glycyrrhizae of the invention, cardamom seed, tuber of multiflower knotweed rhizome, Radix Astragali, pueraria lobata, Chinese pepper, radix paeoniae rubra, rheum officinale, uncaria hook, Sophora, dry aconite root, Chinese ephedra, Chinese Bats Pueraria lobota, galangal, extract have the induced activity of expression BDNF genes, Chinese medicine, for can be used for improving brain disorder using these independent herbal medicine, their mixture or these herbal medicine and other herbal medicine, with phrenoblabia neurodegenerative disease, such as depression and Alzheimer disease.
