BROLY, HERVE,PONCE JR., RAFAEL A.,GRAFFNER, HANS OTTO LENNART,PEANO, SERGIO
申请号：
PL10167232
公开号：
PL2233149T3
申请日:
2008.10.16
申请国别(地区):
PL
年份:
2016
代理人:
摘要：
A therapeutically effective amount of an extracellular domain of a transmembrane activator and calcium modulator and cyclophilin ligand-interactor (TACI) polypeptide comprising a secreted form of SEQ ID NO:23 and an anti-CD-20 agent comprising rituximab, for use in reducing B cell numbers in a mammal, wherein said therapeutically effective amount results in a synergistic reduction in the number of memory B cells.
