SCHULTZE, Kornelia,BLANUSA, Milan,SHUSTER, Andrea Claudia,JOYCE-SHAIKH, Barbara,ZUNIGA, Luis, A.
申请号：
CR20190459
公开号：
CR20190459A
申请日:
2018.04.05
申请国别(地区):
CR
年份:
2020
代理人:
摘要：
The antibody and antigen binding fragments provided by the invention are combined with the strategic approach to international chemicals management 4 (immunoglobulin 4 transcripts), for example, with the anti-pd1 antibody. In addition, procedures for the use of these antibodies, such as procedures for the treatment or prevention of cancer in patients, and procedures for the preparation of such antibodies, are specified. fragment. Present invention provides antibiodies and antigean-binding fragments thereof that bind to ILT4（immunoglobulin-like transcript 4）and combinations thereof， E.With an anti PD1 bomb There are also ways to treat or prevent cancer in a project； and ways to make this antibiotic and debris happen.La presente invención proporciona anticuerpos y fragmentos de unión a antígeno de los mismos que se unen a ILT4 (transcrito de tipo inmunoglobulina 4) y combinaciones de los mismos, por ejemplo, con un anticuerpo anti-PD1. También se proporcionan procedimientos de uso de los mismos, por ejemplo, para tratar o prevenir el cáncer en un sujeto； y procedimientos de preparación de dichos anticuerpos y fragmentos.The present invention provides antibodies and antigen-binding fragments thereof that bind to ILT4 (immunoglobulin-like transcript 4) and combinations thereof, e.g., with an anti-PD1 antibody. Also provided are methods of use thereof, for example, for treating or preventing cancer in a subject； and methods of making such antibodies and fragments.
