The Arizona Board of Regents on Behalf of the University of Arizona;The Regents of the University of California
发明人:
Eugene W. Gerner,Jason A. Zell,Christine E. McLaren,Frank L. Meyskens, Jr.,Hoda Anton-Culver,Particia A. Thompson
申请号：
US14841750
公开号：
US09937141B2
申请日:
2015.09.01
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention provides methods and kits a) for predicting colorectal cancer patient survival, as well as the survival of patients harboring other invasive cancers where cellular proliferation and carcinogenesis is linked, in part, to high levels of ODC activity and increased cellular polyamine contents, and b) for selecting the corresponding treatment options for such patients based on the allelic nucleotide sequence or SNP at position +316 of the ODC1 promoter gene as well as cancer treatment methods, in each case, which include the determination of the ODC1 promoter +316 position genotype, as a means to guide treatment selection.
