CHILDRENS MEDICAL CENTER CORPORATION;CHILDREN'S MEDICAL CENTER CORPORATION
发明人:
HE, ZHIGANG,JIN, DUO,SUN, FANG
申请号：
EP12845212
公开号：
EP2773382A4
申请日:
2012.11.01
申请国别(地区):
EP
年份:
2016
代理人:
摘要：
Disclosed herein is a method of promoting sustained survival, sustained regeneration, in a lesioned mature neuron, sustained compensatory outgrowth in a neuron, or combinations thereof. The method comprises contacting the lesioned mature neuron with an effective amount of an inhibitor of PTEN and an effective amount of an inhibitor of SOCS3 to thereby promote survival and/or regeneration and/or compensatory outgrowth of the neuron. Therapeutic methods of treatment of a subject with a neuronal lesion by administration of a therapeutically effective amount of an inhibitor of PTEN and a therapeutically effective amount of an inhibitor of SOCS3, are also disclosed, as are pharmaceutical compositions and devices for use in the methods.
