Methods and systems of treating a hoof on an ungulate mammal involve delivering reduced pressure to an interior portion of a hoof to promote profusion. In one instance, a method includes forming one or more apertures in a hoof wall of the hoof proximate to laminae that is proximate to a phalanx (P3) of the hoof, disposing a distribution manifold proximate to the one or more apertures, covering the distribution manifold and a portion of the ungulate mammals exterior tissue with a sealing member to form a sealed space in which the distribution manifold is disposed, and providing reduced pressure to the distribution manifold in the sealed space. Other methods and systems are also presented.