KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY;PUSAN NATIONAL UNIVERSITY INDUSTRY—UNIVERSITY COOPERATION FOUNDATION;GACHON UNIVERSITY OF INDUSTRY—ACADEMIC COOPERATION FOUNDATION
发明人:
Hyun Jong Paik,Jae Kwang Song,Seong Soo An,Chae Yeon Lee,Jong Hwa Jeong,Mohammad Abdul Kadir,Tae Heon Lee
申请号：
US14778906
公开号：
US09757342B2
申请日:
2013.10.11
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention relates to a method for preparing a protein cage which comprises: a 1st step of preparing an amphiphilic polymer comprising a 1st hydrophobic polymer and a 1st hydrophilic functional group； a 2nd step of preparing a hydrophilic protein comprising a 2nd functional group binding to the 1st functional group； a 3rd step of forming an amphiphilic polymer-protein hybrid by the binding of the 1st functional group and the 2nd functional group, and forming core-shell structured particles comprising a protein shell and an amphiphilic polymer core by the self-assembly of the amphiphilic polymer in a hydrophilic solvent； and a fourth step of removing some or all of the hydrophobic polymer of the core part from the core-shell structured particles.
