THE PRESENT INVENTION DESCRIBES THE NOVEL 18-METHYL-19-NORANDROST-4-ENE 17, 17-SPIRO ETHERS OF THE GENERAL FORMULA I IN WHICH Z IS AN OXYGEN ATOM, TWO HYDROGEN ATOMS, A GROUP =NOR OR =NNHSO2R, WHERE R IS A HYDROGEN ATOM OR A STRAIGHT- OR BRANCHED-CHAIN ALKYL GROUP HAVING 1 TO 4 OR 3 TO 4 CARBON ATOMS, R4 IS A HYDROGEN ATOM, A HALOGEN ATOM OR A TRIFLUOROMETHYL GROUP, AND R6 AND/OR R7 MAY HAVE α OR β CONFIGURATION, AND R6 AND R7 ARE INDEPENDENTLY OF ONE ANOTHER A HYDROGEN ATOM OR A STRAIGHT- OR BRANCHED-CHAIN ALKYL GROUP HAVING 1 TO 4 OR 3 TO 4 CARBON ATOMS OR A STRAIGHT- OR BRANCHED- CHAIN ALKENYL GROUP HAVING 2 TO 4 OR 3 TO 4 CARBON ATOMS OR A SATURATED CYCLOALKYL GROUP HAVING 3 TO 5 CARBON ATOMS OR TOGETHER ARE A METHYLENE GROUP OR A DOUBLE BOND. THE NOVEL COMPOUNDS HAVE PROGESTATIONAL AND ANTIMINERALOCORTICOID ACTIVITY.
