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СОЕДИНЕНИЯ ДЛЯ ЛЕЧЕНИЯ РАКА
专利权人:
Джи Ти Икс; ИНК. (US)
发明人:
ДОЛТОН Джеймс Т. (US),МИЛЛЕР Дуэйн Д. (US),АН Суньцзо (US),ЧЭНЬ Цзяньцзунь (US),ДЬЮК Чарльз (US),ЛИ Чиень-Мин (US),ЛИ Вэй (US),ЛУ Янь (US),ВАН Чжао (US)
申请号:
RU2012141590/04
公开号:
RU2012141590A
申请日:
2010.12.29
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. A compound represented by the structure of formula (II): represents gdeV soboy- (imidazole) R, R, R, R, r and independently represent a hydrogen atom, O-alkyl,, O-haloalkyl, F, Cl, Br, I, haloalkyl, CF, CN, -CHCN, NH, OH, - (CH) NHCH, - (CH) NH, - (CH) N (CH), -OC (O) CF, C-Clineyny or branched alkyl, haloalkyl, alkylamino, aminoalkyl, -OCHPh, -NHCO-alkyl, COOH, -C (O) Ph, C (O) O-alkyl, C (O) H, -C (O) NHili NO r and independently represent a hydrogen atom, O-alkyl, O-haloalkyl, F, Cl, Br, I, haloalkyl, CF, CN, -CHCN, NH, OH, - (CH) NHCH, - (CH) NH, - (CH) N (CH), -OC (O) CF, C-Clineyny or branched alkyl, haloalkyl, and lkilamino, aminoalkyl, -OCHPh, -NHCO-alkyl, COOH, -C (O) Ph, C (O) O-alkyl, C (O) H, -C (O) NHili NO X represents a bond, C- Cuglevodorod or O Y represents a bond, C = O, -C = S, -C = N-NH, -C = N-OH, -CH-OH, -C = CH-CN -C = N-CN, -CH = CH-, -C = C (CH), -C = N-OMe, - (C = O) -NH, -NH- (C = O), - (C = O) -O, -O- (C = O), - (CH) - (C = O), (C = O) - (CH), - (SO) -NH-, -NH- (SO) - , SO, SO, or S i is an integer from 0 to 5 1 is an integer from 1 to 2 n is an integer from 1 to 3 and m represents an integer from 1 to 3 2. A compound according to claim 1, wherein said compound represented by the structure of formula V: wherein R, R, R, n and B are as defined at point 1.3. A compound according to claim 1, wherein said compound represented by the structure of formula (XVI): wherein R independently represent H, O-alkyl, I, Br, Cl, F, alkyl, haloalkyl, aminoalkyl, - (CH) NHCH, - (CH ) NH, - (CH) N (CH), OCHPh, OH, CN, NO, -NHCO-alkyl, COOH, C (O) O-alkyl or C (O) H R is I, Br, Cl or F i is an integer from 0 to 5 and n is equal to 1-4.4. A compound according to claim 3, wherein said R is F.5. A compound according to claim 3, wherein said R is Cl.6. A compound according to claim 3, wherein said R is Cl.7. A compound according to claim 3, wherein said R is OSN.8. conn1. Соединение, представленное структурой формулы (II):гдеВ представляет собой-(имидазол)R1,
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