A therapeutic agent for advanced immune demyelinating disease containing an anti-CD27 antibody or antigen-binding fragment thereof, or an anti-CD226 antibody or antigen-binding fragment thereof as an active ingredient, and an expression suppressing substance for suppressing the expression of Eomes gene as an active ingredient A therapeutic agent for advanced immunodefying demyelinating disease or an activity inhibiting substance for inhibiting the activity of a cytotoxic protease, which comprises a therapeutic agent for progressive immune demyelinating disease.抗CD27抗体若しくはその抗原結合性断片、又は抗CD226抗体若しくはその抗原結合性断片を有効成分として含有する進行型免疫性脱髄疾患治療剤、Eomes遺伝子の発現を抑制する発現抑制物質を有効成分として含有する進行型免疫性脱髄疾患治療剤、又は細胞障害性プロテアーゼの活性を阻害する活性阻害物質を有効成分として含有する進行型免疫性脱髄疾患治療剤。
