Gregory T. Went;Timothy J. Fultz;Laurence R. Meyerson
发明人:
Gregory T. Went,Timothy J. Fultz,Laurence R. Meyerson
申请号：
US13536588
公开号：
US20120264782A1
申请日:
2012.06.28
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The invention provides compositions comprising extended release memantine in combination with immediate release donepezil to a subject. Memantine in an extended release form containing 22.5 to 30 mg memantine or a pharmaceutically acceptable salt thereof in combination with donepezil achieves particular pharmacokinetic criteria such as change in plasma concentration of memantine over time and ratio of maximum memantine plasma concentration to mean memantine plasma concentration.
