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四氫吖唉衍生物及其前藥
专利权人:
DAIICHI SANKYO COMPANY; LIMITED
发明人:
MARUOKA, HIROSHI,丸冈博,丸岡博,NOJI, TOSHIHARU,野地寿治,野地壽治,MURAFUJI, HIDENOBU,村藤秀宣,TSUNEMI, TOMOYUKI,常深智之,TAKAHASHI, JUNKO,高桥纯子,高橋純子,UESUGI, SHUHEI,上杉修平,TOMITA, URARA,富田丽,富田麗
申请号:
TW108119674
公开号:
TW202016071A
申请日:
2019.06.06
申请国别(地区):
TW
年份:
2020
代理人:
摘要:
The present invention addresses the problem of providing a compound that is useful as a therapeutic or prophylactic for diseases related to the immune system, particularly autoimmune diseases such as systemic lupus erythematosus (SLE) and lupus hepatitis in SLE patients, the compound being useful as a result of inhibiting the function of immune cells by inhibiting activated T-cell proliferation or by inhibiting the production of interferon alpha (IFN-[alpha]) by activated plasmacytoid dendritic cells (pDC). The present invention provides a compound represented by general formula (I) [in the formula, X, R1, R2, R3, R4, R5, and R6 are as defined in the specification] or a pharmaceutically acceptable salt thereof.本發明之課題在於提供一種有用的化合物,其係藉由抑制活化T細胞的增生、或抑制因經活化之漿細胞樣樹突細胞(plasmacytoid dendritic cell)(pDC)所致之干擾素α(interferon alpha)(IFN-α)的產生,而抑制免疫細胞的功能,以作為免疫系統相關之疾病,特別是作為全身性紅斑狼瘡(systemic lupus erythematosus)(SLE)及在SLE患者中之狼瘡性腎炎(lupus nephritis)等自體免疫疾病的治療或預防藥。本發明提供一種通式(I)所示之化合物或其藥學上可容許的鹽:[式中,X、R1、R2、R3、R4、R5及R6如說明書所載]。
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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