The invention describes methods and agents for improving cosmetic appearance,for promoting, improving orrestoring health of cells and tissues, preferably skin, and more preferably,for restoring aged or damaged skin to a healthyappearance. This invention relates to the use of cells and cellular extractsin rejuvenation and healing technologies thereby improvinghealing and regeneration of all bodily tissues and organs. The presentinvention relates to compositions and methods of managing,preventing, and treating scars. The invention also relates to prevention ofdeterioration, damage and malfunction of cells and tissues,and to promote, improve or exceed cellular function in order to promote,improve and exceed appearance, vitality andhealth. In some embodiments, the invention relates to compositions of cells,eggs, cell extracts, egg extracts, and extractcomponents such as purified nucleic acids, polypeptides, lipids, carbohydratesor other natural products.