SAMPSON PETER BRENT,LIU YONG,LI SZE-WAN,FORREST BRYAN T.,PAULS HEINZ W.,EDWARDS LOUISE G,FEHER MIKLOS,PATEL NARENDRA KUMAR B.,LAUFER RADOSLAW,PAN GUOHUA
申请号：
NZ60235011
公开号：
NZ602350A
申请日:
2011.04.06
申请国别(地区):
NZ
年份:
2014
代理人:
摘要：
Disclosed herein are spiro-cyclopropyl-indolinone compounds, and the use thereof as kinase inhibitors in the treatment of a cancer, such as lung cancer, breast cancer, colon cancer, brain cancer, neuroblastoma, prostate cancer, melanoma, glioblastoma multiform, ovarian cancer, lymphoma, leukemia, melanoma, sarcoma, paraneoplasia, osteosarcoma, germinoma, glioma and mesothelioma. In one embodiment the compound is (1R,2S)-(E)-5&rsquo；-fluoro-2-{ 3-(4-(morpholinomethyl)styryl-1H-indazol-6-yl)spiro[cyclopropane-1,3&rsquo；-indolin]-2&rsquo；-one 2,2,2-trifluoroacetate.
