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MODULATION OF SPLENOCYTES IN CELL THERAPY
专利权人:
ABT HOLDING COMPANY
发明人:
ROBERT W. MAYS
申请号:
SG10201503700W
公开号:
SG10201503700WA
申请日:
2011.05.12
申请国别(地区):
SG
年份:
2015
代理人:
摘要:
The invention provides methods for treating pathological conditions associated with an undesirable inflammatory component. The invention is generally directed to reducing inflammation by administering cells that have one or more of the following effects in an injured subject: interact with splenocytes, preserve splenic mass, increase proliferation of CD4+ and CD8+ T-cells, increase IL-4 and IL-10, decrease IL-6 and IL-1β, and increase M2:M1 macrophage ratio at the site of injury. The invention is also directed to drug discovery methods to screen for agents that modulate the ability of the cells to have these effects. The invention is also directed to cell banks that can be used to provide cells for administration to a subject, the banks comprising cells having desired potency for achieving these effects.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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