János BORBÉLY,István HAJDÚ,Magdolna BODNÁR,Ildikó SCRIFFERTNÉ DENYICSKA
申请号：
US13888675
公开号：
US20130302255A1
申请日:
2013.05.07
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Disclosed are novel, targeting, paramagnetic nanoparticles as contrast agent for magnetic resonance imaging. The compositions of the nanoparticles are composed of self-assembled polyelectrolyte biopolymers having targeting moieties, which can suitable for targeted delivery of paramagnetic ions complexed to the nanoparticles. The nanoparticulate contrast agent can internalize into the targeted tumor cells to realize the receptor mediated uptake, and therefore afford enhanced relaxivity and improved signal-to-noise effect on the examined tissue areas. Methods for making these targeting MRI contrast agents are also provided.
