It is an object of the present invention to provide a treatment agent and apreventive agent for osteoarthritis and arthritis (arthromeningitis) derivedfromosteoarthritis.[Means for solving problem(s)]The present invention is based on a knowledge that the use of ananti-Fas IgM antibody allows the alleviation of an osteoarthritis symptom.Specifically, the present invention is based on a knowledge that the use of ananti-Fas IgM antibody allows the inhibition of production of a cartilagematrixdegrading enzyme. Furthermore, the present invention is based on a knowledgethat the use of an anti-Fas IgM antibody can improve the ability to produce acartilage matrix.
