BARBOUR, Robin,ALEXANDER, Svetlana,RENZ, Mark E.,GAI, Shuning,NIJJAR, Tarlochan S.,DOLAN, Philip James
申请号：
PE2019002189
公开号：
PE20200695A1
申请日:
2018.05.02
申请国别(地区):
PE
年份:
2020
代理人:
摘要：
It refers to a humanized or chemical antibody 5g8 specifically bound to tau people. 5g8 is a mouse antibody, which consists of a mature heavy chain variable region SEQ ID No.7 and a mature light chain variable region SEQ ID No.8. Among them, the heavy chain variable region of human maturity includes three CDRs with SEQ ID No: 11-13, while the light chain variable region of human maturity includes three CDRs with SEQ ID No: 14-16. He also mentioned a pharmacological component that contains effective antibodies in the treatment of Alzheimer's disease, Down syndrome, and mild cognitive impairment.SE REFIERE A UN ANTICUERPO 5G8 HUMANIZADO O QUIMERICO QUE SE UNE ESPECIFICAMENTE A TAU HUMANA, DONDE 5G8 ES UN ANTICUERPO DE RATON QUE COMPRENDE UNA REGION VARIABLE DE CADENA PESADA MADURA DE SEQ ID NO:7 Y UNA REGION VARIABLE DE CADENA LIGERA MADURA DE SEQ ID NO:8, DONDE LA REGION VARIABLE DE CADENA PESADA MADURA HUMANIZADA COMPRENDE TRES CDR DE SEQ ID NO: 11-13 Y LA REGION VARIABLE DE CADENA LIGERA MADURA HUMANIZADA COMPRENDE TRES CDR DE SEQ ID NO: 14-16. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE CONTIENE DICHO ANTICUERPO UTIL EN EL TRATAMIENTO DE LA ENFERMEDAD DE ALZHEIMER, EL SINDROME DE DOWN, EL DETERIORO COGNITIVO LEVE
