A portable, mechanical compression device for preventing or treating deep vein thrombosis and extremity edema is provided herein. The device includes a frame that is placed in whole or in part around a limb, and a plurality of compression units that compress the limb, thereby mechanically facilitating circulation. A user (e.g., wearer or helper) moves the device along the limb, thereby moving the point of compression along the limb in the direction of the movement of the device, facilitating blood flow through the limb, thereby lessening the chance of a clot formation within the deep veins of the limb and decreasing stasis of fluid or blood in the limb.