Barrett R. HARVEY,Kenneth L. PINKSTON,Ali AZHDARINA,Eva M. SEVICK-MURACA
申请号：
US14774795
公开号：
US20160024207A1
申请日:
2014.03.12
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Embodiments of the invention provide high affinity recombinant EpCAM-binding antibodies. Methods of using a such antibodies as imaging agents, diagnostics and therapeutics are also provided. Dual-nuclear and fluorescently labeled or singly fluorescently labeled contrast agents promise the advantage of molecularly-guided surgical resection via surgical field near-infrared fluorescence (NIRF) imaging following (in the case of dual labeled agents) nuclear imaging for general localization. Currently, nodal staging of most cancers is performed following lymph node (LN) biopsy and dissection for subsequent pathological examination.
