Robert M. Scarborough;Hans-Michael Jantzen;Charles K. Marlowe;Kim A. Kane-Maguire;David M. Sedlock;Wolin Huang
发明人:
Robert M. Scarborough,Hans-Michael Jantzen,Wolin Huang,David M. Sedlock,Charles K. Marlowe,Kim A. Kane-Maguire
申请号：
US13270193
公开号：
US08524721B2
申请日:
2011.10.10
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Novel compounds of formulae (I) and (VIII), which more particularly include sulfonylurea derivatives, sulfonylthiourea derivatives, sulfonylguanidine derivatives, sulfonylcyanoguanidine derivatives, thioacylsulfonamide derivatives, and acylsulfonamide derivatives which are effective platelet ADP receptor inhibitors. These derivatives may be used in various pharmaceutical compositions, and are particularly effective for the prevention and/or treatment of cardiovascular diseases, particularly those diseases related to thrombosis. The invention also relates to a method for preventing or treating thrombosis in a mammal comprising the step of administering a therapeutically effective amount of a compound of formulae (I) to (VIII), or a pharmaceutically acceptable salt thereof.
