ONO PHARMACEUTICAL CO., LTD.;小野药品工业株式会社;小野藥品工業株式會社
发明人:
山本真吾,吉泽敏男,吉澤敏男
申请号：
MOJ002042
公开号：
MOJ002042B
申请日:
2016.02.12
申请国别(地区):
MO
年份:
2016
代理人:
摘要：
6- amino -9- [(3R) -1- (2- butine acyl group) -3- pyrrolidinyl] -7- (4- Phenoxyphenyl) -7,Bis- Hydrogen -8H- purine -8- Tong Which Suan Which of 9-, with the qualitative Gifted Iso of Btk Election Select inhibitory activity, Dai Xie Steady, in addition, It is the compound of Needles Right You From Alkaline base dissolubility and absorbability Gifted Iso, Neng Knot crystalline substance, therefore the disease of the compound Ke Zuo Wei With B Fine born of the same parents and/or hypertrophy Fine Bao Xiang Off control Treatment Elixirs.6-氨基-9-[(3R)-1-(2-丁炔酰基)-3-吡咯烷基]-7-(4-苯氧基苯基)-7,9-二氫-8H-嘌呤-8-酮鹽酸鹽，具有Btk選擇性抑制活性、代謝穩定性優異，此外，還是針對游離鹼基溶解性和吸收性優異、能結晶的化合物，因此所述化合物可作爲與B細胞和/或肥大細胞相關的疾病的治療劑。
