Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
发明人:
申请号：
EP16865148.7
公开号：
EP3373958A4
申请日:
2016.11.11
申请国别(地区):
EP
年份:
2019
代理人:
摘要：
Disclosed herein are methods and compositions useful for preventing or reducing corneal haze of opacification resulting from Limbal Stem Cell Deficiency (LSCD). The invention comprises a method of preventing or treating corneal opacification, comprising administering to a subject a sufficient amount of a proteasome modulator. The invention also comprises a method of preventing or treating corneal opacification, comprising administering to a subject a sufficient amount of a proteasome modulator. In addition, the invention comprises a method of administering to a subject suffering from corneal opacification with a sufficient amount of proteasome modulator, resulting in reduction of Keratin proteins in the cornea of the subject.
